CVS Health EDI Requirements
CVS Health requires full EDI with GS1-128 labeling and matching ASNs from all suppliers — a requirement it extended to its smallest vendors starting in 2024. The ASN is the largest chargeback source, and invoices must be electronic and match the PO exactly.
Required EDI documents
| Document | Name | Notes |
|---|---|---|
| EDI 850 | Purchase Order | required |
| EDI 855 | PO Acknowledgment | agreement-dependent |
| EDI 856 | Advance Ship Notice (ASN) | required; must precede the shipment |
| EDI 810 | Invoice | required; must be electronic |
| EDI 820 | Remittance | agreement-dependent |
| EDI 832 | Price/Sales Catalog | agreement-dependent |
| EDI 846 | Inventory Advice | agreement-dependent |
| EDI 852 | Product Activity Data | agreement-dependent |
| EDI 997 | Functional Acknowledgment | required |
Labeling & packaging
- GS1-128 labels with matching ASNs are mandatory for all suppliers (extended to the smallest vendors starting 2024).
- SSCC on cartons; label data must match the 856.
Connection & portal
- ANSI X12 with VAN, AS2, or FTP. EDI setup is arranged through a CVS contact to obtain a setup form.
- Drop-ship via CommerceHub/Rithum is a common industry pattern but isn’t confirmed CVS-specific — verify.
Onboarding & testing
A mandatory test cycle covers the 850/856/810 before go-live. CVS-specific calendar timelines aren’t published publicly.
Compliance & chargebacks
- • A missing or late ASN is reported as an immediate chargeback trigger and the largest source of deductions.
- • Paper invoices are reported to incur a financial penalty — the 810 must be electronic — and invoices must match the PO exactly on quantity, item, and price.
- • The ASN must arrive at the CVS DC before the physical shipment. Specific dollar amounts aren’t published publicly.
Worth knowing
- • Full EDI + GS1-128 + matching ASN is required regardless of supplier size.
- • Pharmacy/Rx-specific rules (e.g., DSCSA serialization) are separate from these supplier-EDI requirements — verify independently for Rx product.
How EndlessEDI helps with CVS Health
EndlessEDI builds accurate, on-time 856s that land before the shipment, keeps the 810 electronic and matched to the PO, and applies GS1-128 labeling — covering CVS’s all-supplier ASN mandate.
Explore EndlessEDICVS Health EDI FAQ
What EDI documents does CVS require?
CVS requires the 850, 856, 810, and 997, with the 855, 820, 832, 846, and 852 agreement-dependent. GS1-128 labeling with a matching ASN is mandatory for all suppliers.
Does CVS require EDI from small suppliers?
Yes. Starting in 2024 CVS extended full EDI with GS1-128 labels and matching ASNs to even its smallest vendors. Paper invoices are reported to incur a penalty — the 810 must be electronic.
EDI requirements and penalty schedules change and vary by program. Figures marked “reported” come from third-party sources, not the retailer’s published fee schedule — always confirm against the retailer’s current routing guide and your vendor agreement.
